RápidoPGS

A rápido and lightweight method to compute Polygenic Risk Scores.

Last update: 2020-08-03

This package allows to quickly (rápido is Spanish for “fast”) compute polygenic scores (PGS) from case-control or quantitative trait GWAS summary statistic datasets, without the need of an external validation dataset.

Background

You can find a description of the ideas behind RápidoPGS, as well as technical details in our preprint:

Reales G, Kelemen M, & Wallace C (2020) RápidoPGS: A rapid polygenic score calculator for summary GWAS data without validation dataset. BioRxiv.

Installation

# RápidoPGS (1.0.2) is now available on CRAN. You can install it by typing the code below
install.packages("RapidoPGS")

Development version

# There's also a development version, that can be installed from GitHub.
library(remotes)
install_github('GRealesM/RapidoPGS')

Documentation

Full documentation and vignettes are available on the website (click on the cat if you’re at the GitHub repo).